Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions

The difficulty of achieving robust functional expression of insect nicotinic acetylcholine receptors (nAChRs) has hampered our understanding of these important molecular targets of globally deployed neonicotinoid insecticides at a time when concerns have grown regarding the toxicity of this chemotyp...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ihara, Makoto, Furutani, Shogo, Shigetou, Sho, Shimada, Shota, Niki, Kunihiro, Komori, Yuma, Kamiya, Masaki, Koizumi, Wataru, Magara, Leo, Hikida, Mai, Noguchi, Akira, Okuhara, Daiki, Yoshinari, Yuto, Kondo, Shu, Tanimoto, Hiromu, Niwa, Ryusuke, Sattelle, David B., Matsuda, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368294/
https://ncbi.nlm.nih.gov/pubmed/32611810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003667117
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