Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1‐chicken β2 nicotinic acetylcholine receptor

BACKGROUND AND PURPOSE: Neonicotinoid insecticides interact with the orthosteric site formed at subunit interfaces of insect nicotinic ACh (nACh) receptors. However, their interactions with the orthosteric sites at α–non α and α–α subunit interfaces remain poorly understood. The aim of this study wa...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Ihara, Makoto, Hikida, Mai, Matsushita, Hiroyuki, Yamanaka, Kyosuke, Kishimoto, Yuya, Kubo, Kazuki, Watanabe, Shun, Sakamoto, Mifumi, Matsui, Koutaro, Yamaguchi, Akihiro, Okuhara, Daiki, Furutani, Shogo, Sattelle, David B, Matsuda, Kazuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Themed Section: Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979822/
https://ncbi.nlm.nih.gov/pubmed/28616862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13914
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