Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells

Folate deprivation drives the instability of a group of rare fragile sites (RFSs) characterized by CGG trinucleotide repeat (TNR) sequences. Pathological expansion of the TNR within the FRAXA locus perturbs DNA replication and is the major causative factor for fragile X syndrome, a sex-linked disord...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Garribba, Lorenza, Bjerregaard, Victoria A., Gonçalves Dinis, Marisa M., Özer, Özgün, Wu, Wei, Sakellariou, Despoina, Pena-Diaz, Javier, Hickson, Ian D., Liu, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368274/
https://ncbi.nlm.nih.gov/pubmed/32601218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921219117
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