Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells

Folate deprivation drives the instability of a group of rare fragile sites (RFSs) characterized by CGG trinucleotide repeat (TNR) sequences. Pathological expansion of the TNR within the FRAXA locus perturbs DNA replication and is the major causative factor for fragile X syndrome, a sex-linked disord...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Garribba, Lorenza, Bjerregaard, Victoria A., Gonçalves Dinis, Marisa M., Özer, Özgün, Wu, Wei, Sakellariou, Despoina, Pena-Diaz, Javier, Hickson, Ian D., Liu, Ying
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368274/
https://ncbi.nlm.nih.gov/pubmed/32601218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921219117
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