Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells

Folate deprivation drives the instability of a group of rare fragile sites (RFSs) characterized by CGG trinucleotide repeat (TNR) sequences. Pathological expansion of the TNR within the FRAXA locus perturbs DNA replication and is the major causative factor for fragile X syndrome, a sex-linked disord...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Garribba, Lorenza, Bjerregaard, Victoria A., Gonçalves Dinis, Marisa M., Özer, Özgün, Wu, Wei, Sakellariou, Despoina, Pena-Diaz, Javier, Hickson, Ian D., Liu, Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368274/
https://ncbi.nlm.nih.gov/pubmed/32601218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921219117
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