STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca(2+) entry with NFAT1 activation

The Orai1 channel is regulated by stromal interaction molecules STIM1 and STIM2 within endoplasmic reticulum (ER)-plasma membrane (PM) contact sites. Ca(2+) signals generated by Orai1 activate Ca(2+)-dependent gene expression. When compared with STIM1, STIM2 is a weak activator of Orai1, but it has...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Son, Ga-Yeon, Subedi, Krishna Prasad, Ong, Hwei Ling, Noyer, Lucile, Saadi, Hassan, Zheng, Changyu, Bhardwaj, Rajesh, Feske, Stefan, Ambudkar, Indu Suresh
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368200/
https://ncbi.nlm.nih.gov/pubmed/32601188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915386117
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