STIM2 enhances receptor-stimulated Ca(2+) signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions

A central component of receptor-evoked Ca(2+) signaling is store-operated Ca(2+) entry (SOCE), which is activated by the assembly of STIM1-Orai1 channels in endoplasmic reticulum (ER) and plasma membrane (PM) (ER-PM) junctions in response to depletion of ER-Ca(2+). We report that STIM2 enhances agon...

Full description

Saved in:
Bibliographic Details
Published in:Sci Signal
Main Authors: Ling Ong, Hwei, Brito de Souza, Lorena, Zheng, Changyu, Tai Cheng, Kwong, Liu, Xibao, Goldsmith, Corinne, Feske, Stefan, Ambudkar, Indu S.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381927/
https://ncbi.nlm.nih.gov/pubmed/25587190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005748
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items