Tumors induce de novo steroid biosynthesis in T cells to evade immunity

Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to evade anti-tumor immunity. Using a transgenic steroidogenesis-reporter mouse line we...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Mahata, Bidesh, Pramanik, Jhuma, van der Weyden, Louise, Polanski, Krzysztof, Kar, Gozde, Riedel, Angela, Chen, Xi, Fonseca, Nuno A., Kundu, Kousik, Campos, Lia S., Ryder, Edward, Duddy, Graham, Walczak, Izabela, Okkenhaug, Klaus, Adams, David J., Shields, Jacqueline D., Teichmann, Sarah A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368057/
https://ncbi.nlm.nih.gov/pubmed/32680985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17339-6
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