The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats

Mitochondrial dysfunction contributes to cardiac pathologies. Barriers to new therapies include an incomplete understanding of underlying molecular culprits and a lack of effective mitochondria-targeted medicines. Here, we test the hypothesis that the cardiolipin-binding peptide elamipretide, a clin...

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Pubblicato in:Commun Biol
Autori principali: Allen, Mitchell E., Pennington, Edward Ross, Perry, Justin B., Dadoo, Sahil, Makrecka-Kuka, Marina, Dambrova, Maija, Moukdar, Fatiha, Patel, Hetal D., Han, Xianlin, Kidd, Grahame K., Benson, Emily K., Raisch, Tristan B., Poelzing, Steven, Brown, David A., Shaikh, Saame Raza
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368046/
https://ncbi.nlm.nih.gov/pubmed/32680996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-1101-3
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