The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats

Mitochondrial dysfunction contributes to cardiac pathologies. Barriers to new therapies include an incomplete understanding of underlying molecular culprits and a lack of effective mitochondria-targeted medicines. Here, we test the hypothesis that the cardiolipin-binding peptide elamipretide, a clin...

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Publicat a:Commun Biol
Autors principals: Allen, Mitchell E., Pennington, Edward Ross, Perry, Justin B., Dadoo, Sahil, Makrecka-Kuka, Marina, Dambrova, Maija, Moukdar, Fatiha, Patel, Hetal D., Han, Xianlin, Kidd, Grahame K., Benson, Emily K., Raisch, Tristan B., Poelzing, Steven, Brown, David A., Shaikh, Saame Raza
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368046/
https://ncbi.nlm.nih.gov/pubmed/32680996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-1101-3
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