The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats

Mitochondrial dysfunction contributes to cardiac pathologies. Barriers to new therapies include an incomplete understanding of underlying molecular culprits and a lack of effective mitochondria-targeted medicines. Here, we test the hypothesis that the cardiolipin-binding peptide elamipretide, a clin...

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Publicado en:Commun Biol
Main Authors: Allen, Mitchell E., Pennington, Edward Ross, Perry, Justin B., Dadoo, Sahil, Makrecka-Kuka, Marina, Dambrova, Maija, Moukdar, Fatiha, Patel, Hetal D., Han, Xianlin, Kidd, Grahame K., Benson, Emily K., Raisch, Tristan B., Poelzing, Steven, Brown, David A., Shaikh, Saame Raza
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368046/
https://ncbi.nlm.nih.gov/pubmed/32680996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-1101-3
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