MCUb Induction Protects the Heart from Post-Ischemic Remodeling

RATIONALE: Mitochondrial Ca(2+) loading augments oxidative metabolism to match functional demands during times of increased work or injury. However, mitochondrial Ca(2+) overload also directly causes mitochondrial rupture and cardiomyocyte death during ischemia-reperfusion injury by inducing mitocho...

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Bibliographic Details
Published in:Circ Res
Main Authors: Huo, Jiuzhou, Lu, Shan, Kwong, Jennifer Q., Bround, Michael J., Grimes, Kelly M., Sargent, Michelle A, Brown, Milton E., Davis, Michael E., Bers, Donald M., Molkentin, Jeffery D.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367751/
https://ncbi.nlm.nih.gov/pubmed/32299299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.316369
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