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Physiological and pathological roles of the mitochondrial permeability transition pore in the heart

Prolonged mitochondrial permeability transition pore (MPTP) opening results in mitochondrial energetic dysfunction, organelle swelling, rupture and typically a type of necrotic cell death. However, acute opening of the MPTP has a critical physiologic role in regulating mitochondrial Ca(2+) handling...

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Bibliografski detalji
Izdano u:Cell Metab
Glavni autori: Kwong, Jennifer Q, Molkentin, Jeffery D
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4616258/
https://ncbi.nlm.nih.gov/pubmed/25651175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.12.001
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