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Physiological and pathological roles of the mitochondrial permeability transition pore in the heart
Prolonged mitochondrial permeability transition pore (MPTP) opening results in mitochondrial energetic dysfunction, organelle swelling, rupture and typically a type of necrotic cell death. However, acute opening of the MPTP has a critical physiologic role in regulating mitochondrial Ca(2+) handling...
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| Pubblicato in: | Cell Metab |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4616258/ https://ncbi.nlm.nih.gov/pubmed/25651175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.12.001 |
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