Zonisamide Ameliorates Cognitive Impairment by Inhibiting ER Stress in a Mouse Model of Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) increases the risk of Alzheimer’s disease (AD)-like dementia and pathology. Endoplasmic reticulum stress (ERS) plays a key role in the development of cognitive impairment in T2DM. Zonisamide (ZNS) was found to suppress ERS-induced neuronal cell damage in the experimen...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: He, Yong-Xiang, Shen, Qi-Ying, Tian, Jia-Hui, Wu, Qian, Xue, Qin, Zhang, Gui-Ping, Wei, Wei, Liu, Ying-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367218/
https://ncbi.nlm.nih.gov/pubmed/32754028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.00192
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