Rational design of antisense oligonucleotides modulating the activity of TLR7/8 agonists

Oligonucleotide-based therapeutics have become a reality, and are set to transform management of many diseases. Nevertheless, the modulatory activities of these molecules on immune responses remain incompletely defined. Here, we show that gene targeting 2′-O-methyl (2′OMe) gapmer antisense oligonucl...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Alharbi, Arwaf S, Garcin, Aurélie J, Lennox, Kim A, Pradeloux, Solène, Wong, Christophe, Straub, Sarah, Valentin, Roxane, Pépin, Geneviève, Li, Hong-Mei, Nold, Marcel F, Nold-Petry, Claudia A, Behlke, Mark A, Gantier, Michael P
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Chemical Biology and Nucleic Acid Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367172/
https://ncbi.nlm.nih.gov/pubmed/32544249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa523
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