Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase

Telomeres cap the ends of eukaryotic chromosomes and distinguish them from broken DNA ends to suppress DNA damage response, cell cycle arrest and genomic instability. Telomeres are elongated by telomerase to compensate for incomplete replication and nuclease degradation and to extend the proliferati...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Awad, Aya, Glousker, Galina, Lamm, Noa, Tawil, Shadi, Hourvitz, Noa, Smoom, Riham, Revy, Patrick, Tzfati, Yehuda
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367169/
https://ncbi.nlm.nih.gov/pubmed/32542379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa503
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