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Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase

Telomeres cap the ends of eukaryotic chromosomes and distinguish them from broken DNA ends to suppress DNA damage response, cell cycle arrest and genomic instability. Telomeres are elongated by telomerase to compensate for incomplete replication and nuclease degradation and to extend the proliferati...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Awad, Aya, Glousker, Galina, Lamm, Noa, Tawil, Shadi, Hourvitz, Noa, Smoom, Riham, Revy, Patrick, Tzfati, Yehuda
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367169/
https://ncbi.nlm.nih.gov/pubmed/32542379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa503
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