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Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs

2′-5′-Oligoadenylate synthetases (OAS) are innate immune sensors of cytosolic double-stranded RNA (dsRNA) and play a critical role in limiting viral infection. dsRNA binding induces allosteric structural changes in OAS1 that reorganize its catalytic center to promote synthesis of 2′-5′-oligoadenylat...

詳細記述

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書誌詳細
出版年:Nucleic Acids Res
主要な著者: Schwartz, Samantha L, Park, Esther N, Vachon, Virginia K, Danzy, Shamika, Lowen, Anice C, Conn, Graeme L
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367156/
https://ncbi.nlm.nih.gov/pubmed/32678884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa513
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