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Activation of the SARS-CoV-2 receptor Ace2 by cytokines through pan JAK-STAT enhancers

ACE2, in concert with the protease TMPRSS2, binds the novel coronavirus SARS-CoV-2 and facilitates its cellular entry. The ACE2 gene is expressed in SARS-CoV-2 target cells, including Type II Pneumocytes (Ziegler, 2020), and is activated by interferons. Viral RNA was also detected in breast milk (Wu...

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Detalles Bibliográficos
Publicado en:SSRN
Main Authors: Hennighausen, Lothar, Lee, Hye Kyung
Formato: Artigo
Idioma:Inglês
Publicado: Social Science Electronic Publishing 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366816/
https://ncbi.nlm.nih.gov/pubmed/32714116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2139/ssrn.3601827
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