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Activation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent Enhancers during Pregnancy

ACE2 binds the coronavirus SARS-CoV-2 and facilitates its cellular entry. Interferons activate ACE2 expression in pneumocytes, suggesting a critical role of cytokines in SARS-CoV-2 target cells. Viral RNA was detected in breast milk in at least seven studies, raising the possibility that ACE2 is exp...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Hennighausen, Lothar, Lee, Hye Kyung
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474886/
https://ncbi.nlm.nih.gov/pubmed/32966801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108199
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