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Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin

Neutrophils are pivotal players in immune defence which includes a process of release of histones and DNA as neutrophil extracellular traps (NETs). Histones, while toxic to invading pathogens, also kill host cells, including neutrophils. Bacteria have evolved mechanisms to escape neutrophils, includ...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Locke, Matthew, Francis, Robert J., Tsaousi, Evgenia, Longstaff, Colin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366688/
https://ncbi.nlm.nih.gov/pubmed/32678135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68584-0
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