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Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin

Neutrophils are pivotal players in immune defence which includes a process of release of histones and DNA as neutrophil extracellular traps (NETs). Histones, while toxic to invading pathogens, also kill host cells, including neutrophils. Bacteria have evolved mechanisms to escape neutrophils, includ...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Locke, Matthew, Francis, Robert J., Tsaousi, Evgenia, Longstaff, Colin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366688/
https://ncbi.nlm.nih.gov/pubmed/32678135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68584-0
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