Genetically modified macrophages accomplish targeted gene delivery to the inflamed brain in transgenic Parkin Q311X(A) mice: importance of administration routes

Cell-based drug delivery systems have generated an increasing interest in recent years. We previously demonstrated that systemically administered macrophages deliver therapeutics to CNS, including glial cell line-derived neurotrophic factor (GDNF), and produce potent effects in Parkinson’s disease (...

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Udgivet i:Sci Rep
Main Authors: Haney, Matthew J., Zhao, Yuling, Fay, James, Duhyeong, Hwang, Wang, Mengzhe, Wang, Hui, Li, Zibo, Lee, Yueh Z., Karuppan, Mohan K., El-Hage, Nazira, Kabanov, Alexander V., Batrakova, Elena V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366622/
https://ncbi.nlm.nih.gov/pubmed/32678262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68874-7
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