GDNF-expressing Macrophages Restore Motor Functions at a Severe Late-stage, and Produce Long-Term Neuroprotective Effects at an Early-stage of Parkinson’s Disease in Transgenic Parkin Q311X(A) Mice

There is an unmet medical need in the area of Parkinson’s disease (PD) to develop novel therapeutic approaches that can stop and reverse the underlying mechanisms responsible for the neuronal death. We previously demonstrated that systemically administered autologous macrophages transfected ex vivo...

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Publicado en:J Control Release
Main Authors: Zhao, Yuling, Haney, Matthew J., Jin, Yeon S., Uvarov, Olga, Vinod, Natasha, Lee, Yueh Z., Langworthy, Benjamin, Fine, Jason P., Rodriguez, Myosotys, El-Hage, Nazira, Kabanov, Alexander V., Batrakova, Elena V.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927551/
https://ncbi.nlm.nih.gov/pubmed/31678095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.10.027
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