Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3′UTR binding

Increasing evidence suggests that in Amyotrophic Lateral Sclerosis (ALS) mutated RNA binding proteins acquire aberrant functions, leading to altered RNA metabolism with significant impact on encoded protein levels. Here, by taking advantage of a human induced pluripotent stem cell-based model, we ai...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Garone, Maria Giovanna, Alfano, Vincenzo, Salvatori, Beatrice, Braccia, Clarissa, Peruzzi, Giovanna, Colantoni, Alessio, Bozzoni, Irene, Armirotti, Andrea, Rosa, Alessandro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366621/
https://ncbi.nlm.nih.gov/pubmed/32678235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68794-6
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