Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3′UTR binding

Increasing evidence suggests that in Amyotrophic Lateral Sclerosis (ALS) mutated RNA binding proteins acquire aberrant functions, leading to altered RNA metabolism with significant impact on encoded protein levels. Here, by taking advantage of a human induced pluripotent stem cell-based model, we ai...

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Udgivet i:Sci Rep
Main Authors: Garone, Maria Giovanna, Alfano, Vincenzo, Salvatori, Beatrice, Braccia, Clarissa, Peruzzi, Giovanna, Colantoni, Alessio, Bozzoni, Irene, Armirotti, Andrea, Rosa, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366621/
https://ncbi.nlm.nih.gov/pubmed/32678235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68794-6
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