Hydrocarbon-stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor

Glucagon-like peptide 1 (GLP-1) is a natural peptide agonist of the GLP-1 receptor (GLP-1R) found on pancreatic β-cells. Engagement of the receptor stimulates insulin release in a glucose-dependent fashion and increases β-cell mass, two ideal features for pharmacologic management of type 2 diabetes....

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Pubblicato in:ACS Chem Biol
Autori principali: Bird, Gregory H., Fu, Accalia, Escudero, Silvia, Godes, Marina, Opoku-Nsiah, Kwadwo, Wales, Thomas E., Cameron, Michael D., Engen, John R., Danial, Nika N., Walensky, Loren D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366314/
https://ncbi.nlm.nih.gov/pubmed/32348108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00308
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