Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor

BACKGROUND: Overexpression of ATP‐binding cassette (ABC) transporter is a major contributor to multidrug resistance (MDR), in which cancer cells acquire resistance to a wide spectrum of chemotherapeutic drugs. In this work, we evaluated the sensitizing effect of sitravatinib, a broad‐spectrum tyrosi...

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Bibliografski detalji
Izdano u:Cancer Commun (Lond)
Glavni autori: Yang, Yuqi, Ji, Ning, Cai, Chao‐Yun, Wang, Jing‐Quan, Lei, Zi‐Ning, Teng, Qiu‐Xu, Wu, Zhuo‐Xun, Cui, Qingbin, Pan, Yihang, Chen, Zhe‐Sheng
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365458/
https://ncbi.nlm.nih.gov/pubmed/32525624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cac2.12040
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