Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity

BACKGROUND & AIMS: Bile acids are important metabolic signaling molecules. Bile acid receptor activation promotes body weight loss and improves glycemic control. The incretin hormone GLP-1 and thyroid hormone activation of T4 to T3 have been suggested as important contributors. Here, we identify...

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Bibliographic Details
Published in:Cell Mol Gastroenterol Hepatol
Main Authors: Donkers, Joanne M., Roscam Abbing, Reinout L.P., van Weeghel, Michel, Levels, Johannes H.M., Boelen, Anita, Schinkel, Alfred H., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363705/
https://ncbi.nlm.nih.gov/pubmed/32330730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.04.009
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