NTCP deficiency in mice protects against obesity and hepatosteatosis

Bile acids play a major role in the regulation of lipid and energy metabolism. Here we propose the hepatic bile acid uptake transporter Na(+) taurocholate cotransporting polypeptide (NTCP) as a target to prolong postprandial bile acid elevations in plasma. Reducing hepatic clearance of bile acids fr...

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發表在:JCI Insight
Main Authors: Donkers, Joanne M., Kooijman, Sander, Slijepcevic, Davor, Kunst, Roni F., Roscam Abbing, Reinout L.P., Haazen, Lizette, de Waart, Dirk R., Levels, Johannes H.M., Schoonjans, Kristina, Rensen, Patrick C.N., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2019
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675549/
https://ncbi.nlm.nih.gov/pubmed/31237863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127197
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