Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide

Unimolecular dual agonists of the glucagon (GCG) receptor (GCGR) and glucagon-like peptide-1 receptor (GLP-1R) are a new class of drugs that are potentially superior to GLP-1R–specific agonists for the management of metabolic disease. The dual-agonist, peptide 15 (P15), is a glutamic acid 16 analog...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Chang, Rulue, Zhang, Xin, Qiao, Anna, Dai, Antao, Belousoff, Matthew J., Tan, Qiuxiang, Shao, Lijun, Zhong, Li, Lin, Guangyao, Liang, Yi-Lynn, Ma, Limin, Han, Shuo, Yang, Dehua, Danev, Radostin, Wang, Ming-Wei, Wootten, Denise, Wu, Beili, Sexton, Patrick M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363120/
https://ncbi.nlm.nih.gov/pubmed/32371397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013793
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