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De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities

De novo protein design represents an attractive approach for testing and extending our understanding of metalloprotein structure and function. Here, we describe our work on the design of DF (Due Ferri or two-iron in Italian), a minimalist model for the active sites of much larger and more complex na...

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Publicado en:Acc Chem Res
Autores principales: Lombardi, Angela, Pirro, Fabio, Maglio, Ornella, Chino, Marco, DeGrado, William F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362765/
https://ncbi.nlm.nih.gov/pubmed/30973707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.accounts.8b00674
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