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Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain of RIPK1 has enabled the development of highly selective small-molecule inhibitors of its kinase activity, which have dem...
Uloženo v:
| Vydáno v: | Nat Rev Drug Discov |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7362612/ https://ncbi.nlm.nih.gov/pubmed/32669658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41573-020-0071-y |
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