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Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis
Hedgehog (HH) signaling is essential for metazoan development. The HH ligand is secreted into the extracellular space by a cell surface protein named Dispatched-1 (DISP1). Here, we report the cryo-EM structure of human DISP1 protein. DISP1 contains 12 transmembrane helices (TMs) and two extracellula...
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| Veröffentlicht in: | Life Sci Alliance |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Life Science Alliance LLC
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7362390/ https://ncbi.nlm.nih.gov/pubmed/32646883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000776 |
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