Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria

Microvascular thrombosis and blood–brain barrier (BBB) breakdown are key components of cerebral malaria (CM) pathogenesis in African children and are implicated in fatal brain swelling. How Plasmodium falciparum infection causes this endothelial disruption and why this occurs, particularly in the br...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Moxon, Christopher A., Alhamdi, Yasir, Storm, Janet, Toh, Julien M. H., McGuinness, Dagmara, Ko, Joo Yeon, Murphy, George, Lane, Steven, Taylor, Terrie E., Seydel, Karl B., Kampondeni, Sam, Potchen, Michael, O’Donnell, James S., O’Regan, Niamh, Wang, Guozheng, García-Cardeña, Guillermo, Molyneux, Malcolm, Craig, Alister G., Abrams, Simon T., Toh, Cheng-Hock
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362376/
https://ncbi.nlm.nih.gov/pubmed/32579667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001258
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