Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria

Microvascular thrombosis and blood–brain barrier (BBB) breakdown are key components of cerebral malaria (CM) pathogenesis in African children and are implicated in fatal brain swelling. How Plasmodium falciparum infection causes this endothelial disruption and why this occurs, particularly in the br...

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Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: Moxon, Christopher A., Alhamdi, Yasir, Storm, Janet, Toh, Julien M. H., McGuinness, Dagmara, Ko, Joo Yeon, Murphy, George, Lane, Steven, Taylor, Terrie E., Seydel, Karl B., Kampondeni, Sam, Potchen, Michael, O’Donnell, James S., O’Regan, Niamh, Wang, Guozheng, García-Cardeña, Guillermo, Molyneux, Malcolm, Craig, Alister G., Abrams, Simon T., Toh, Cheng-Hock
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2020
Matèries:
Vascular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362376/
https://ncbi.nlm.nih.gov/pubmed/32579667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001258
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