Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria

Microvascular thrombosis and blood–brain barrier (BBB) breakdown are key components of cerebral malaria (CM) pathogenesis in African children and are implicated in fatal brain swelling. How Plasmodium falciparum infection causes this endothelial disruption and why this occurs, particularly in the br...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood Adv
Auteurs principaux: Moxon, Christopher A., Alhamdi, Yasir, Storm, Janet, Toh, Julien M. H., McGuinness, Dagmara, Ko, Joo Yeon, Murphy, George, Lane, Steven, Taylor, Terrie E., Seydel, Karl B., Kampondeni, Sam, Potchen, Michael, O’Donnell, James S., O’Regan, Niamh, Wang, Guozheng, García-Cardeña, Guillermo, Molyneux, Malcolm, Craig, Alister G., Abrams, Simon T., Toh, Cheng-Hock
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2020
Sujets:
Vascular Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362376/
https://ncbi.nlm.nih.gov/pubmed/32579667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001258
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