HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia

In mammalian cells, cytosines found within cytosine guanine dinucleotides can be methylated to 5-methylcytosine (5-mC) by DNA methyltransferases and further oxidized by the Ten-eleven translocation dioxygenase (TET) enzymes to 5-hydroxymethylcytosine (5-hmC). We have previously shown that hematopoie...

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Bibliographic Details
Published in:Blood Adv
Main Authors: Cao, John Z., Liu, Hui, Wickrema, Amittha, Godley, Lucy A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362358/
https://ncbi.nlm.nih.gov/pubmed/32634239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001535
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