TET2 deficiency leads to stem cell factor–dependent clonal expansion of dysfunctional erythroid progenitors

Myelodysplastic syndromes (MDSs) are clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis. Anemia is the defining cytopenia of MDS patients, yet the molecular mechanisms for dyserythropoiesis in MDSs remain to be fully defined. Recent studies have revealed that heteroz...

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Veröffentlicht in:Blood
Hauptverfasser: Qu, Xiaoli, Zhang, Shijie, Wang, Shihui, Wang, Yaomei, Li, Wei, Huang, Yumin, Zhao, Huizhi, Wu, Xiuyun, An, Chao, Guo, Xinhua, Hale, John, Li, Jie, Hillyer, Christopher D., Mohandas, Narla, Liu, Jing, Yazdanbakhsh, Karina, Vinchi, Francesca, Chen, Lixiang, Kang, Qiaozhen, An, Xiuli
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2018
Schlagworte:
Red Cells, Iron, and Erythropoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265651/
https://ncbi.nlm.nih.gov/pubmed/30254129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-05-853291
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