Molecular Basis for Ser/Thr Specificity in PKA Signaling

cAMP-dependent protein kinase (PKA) is the major receptor of the second messenger cAMP and a prototype for Ser/Thr-specific protein kinases. Although PKA strongly prefers serine over threonine substrates, little is known about the molecular basis of this substrate specificity. We employ classical en...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Knape, Matthias J., Wallbott, Maximilian, Burghardt, Nicole C. G., Bertinetti, Daniela, Hornung, Jan, Schmidt, Sven H., Lorenz, Robin, Herberg, Friedrich W.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7361990/
https://ncbi.nlm.nih.gov/pubmed/32630525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9061548
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