Divalent Metal Ions Mg(2+) and Ca(2+) Have Distinct Effects on Protein Kinase A Activity and Regulation

cAMP-dependent protein kinase (PKA) is regulated primarily in response to physiological signals while nucleotides and metals may provide fine-tuning. PKA can use different metal ions for phosphoryl transfer, yet some, like Ca(2+), do not support steady-state catalysis. Fluorescence Polarization (FP)...

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Publicado no:ACS Chem Biol
Main Authors: Knape, Matthias J., Ahuja, Lalima G., Bertinetti, Daniela, Burghardt, Nicole C.G., Zimmermann, Bastian, Taylor, Susan S., Herberg, Friedrich W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714867/
https://ncbi.nlm.nih.gov/pubmed/26200257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00271
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