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eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition
RNA-activated protein kinase (PKR) is a major innate immune factor that senses viral double-stranded RNA (dsRNA) and phosphorylates eukaryotic initiation factor (eIF) 2α. Phosphorylation of the α subunit converts the eIF2αβγ complex into a stoichiometric inhibitor of eukaryotic initiation factor eIF...
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| 發表在: | mBio |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7360930/ https://ncbi.nlm.nih.gov/pubmed/32665273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00976-20 |
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