Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells

Inspired by recent proteomic data demonstrating the upregulation of carbon and glycogen metabolism in aging human hematopoietic stem and progenitor cells (HPCs, CD34+ cells), this report addresses whether this is caused by elevated glycolysis of the HPCs on a per cell basis, or by a subpopulation th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Poisa-Beiro, Laura, Thoma, Judith, Landry, Jonathan, Sauer, Sven, Yamamoto, Akihisa, Eckstein, Volker, Romanov, Natalie, Raffel, Simon, Hoffmann, Georg F., Bork, Peer, Benes, Vladimir, Gavin, Anne-Claude, Tanaka, Motomu, Ho, Anthony D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360735/
https://ncbi.nlm.nih.gov/pubmed/32665666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68396-2
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