E2F-dependent transcription determines replication capacity and S phase length

DNA replication timing is tightly regulated during S-phase. S-phase length is determined by DNA synthesis rate, which depends on the number of active replication forks and their velocity. Here, we show that E2F-dependent transcription, through E2F6, determines the replication capacity of a cell, def...

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Publicat a:Nat Commun
Autors principals: Pennycook, Betheney R., Vesela, Eva, Peripolli, Silvia, Singh, Tanya, Barr, Alexis R., Bertoli, Cosetta, de Bruin, Robertus A. M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360579/
https://ncbi.nlm.nih.gov/pubmed/32665547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17146-z
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