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High-throughput screening reveals higher synergistic effect of MEK inhibitor combinations in colon cancer spheroids
Drug combinations have been proposed to combat drug resistance, but putative treatments are challenged by low bench-to-bed translational efficiency. To explore the effect of cell culture format and readout methods on identification of synergistic drug combinations in vitro, we studied response to 21...
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| Vydáno v: | Sci Rep |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7360566/ https://ncbi.nlm.nih.gov/pubmed/32665693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68441-0 |
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