Loss of α(2)δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes

Reduced pancreatic β-cell function or mass is the critical problem in developing diabetes. Insulin release from β-cells depends on Ca(2+) influx through high voltage– gated Ca(2+) channels (HVCCs). Ca(2+) influx also regulates insulin synthesis and insulin granule priming and contributes to β-cell e...

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Publicado no:Diabetes
Main Authors: Mastrolia, Vincenzo, Flucher, Sylvia M., Obermair, Gerald J., Drach, Mathias, Hofer, Helene, Renström, Erik, Schwartz, Arnold, Striessnig, Jörg, Flucher, Bernhard E., Tuluc, Petronel
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360433/
https://ncbi.nlm.nih.gov/pubmed/28115397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0336
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