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Computer modeling of siRNA knockdown effects indicates an essential role of the Ca(2+) channel α(2)δ-1 subunit in cardiac excitation–contraction coupling
L-type Ca(2+) currents determine the shape of cardiac action potentials (AP) and the magnitude of the myoplasmic Ca(2+) signal, which regulates the contraction force. The auxiliary Ca(2+) channel subunits α(2)δ-1 and β(2) are important regulators of membrane expression and current properties of the...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1904133/ https://ncbi.nlm.nih.gov/pubmed/17563358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700577104 |
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