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Computer modeling of siRNA knockdown effects indicates an essential role of the Ca(2+) channel α(2)δ-1 subunit in cardiac excitation–contraction coupling

L-type Ca(2+) currents determine the shape of cardiac action potentials (AP) and the magnitude of the myoplasmic Ca(2+) signal, which regulates the contraction force. The auxiliary Ca(2+) channel subunits α(2)δ-1 and β(2) are important regulators of membrane expression and current properties of the...

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Bibliografski detalji
Glavni autori: Tuluc, Petronel, Kern, Georg, Obermair, Gerald J., Flucher, Bernhard E.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904133/
https://ncbi.nlm.nih.gov/pubmed/17563358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700577104
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