A Ca(V)1.1 Ca(2+) Channel Splice Variant with High Conductance and Voltage-Sensitivity Alters EC Coupling in Developing Skeletal Muscle

The Ca(2+) channel α(1S) subunit (Ca(V)1.1) is the voltage sensor in skeletal muscle excitation-contraction (EC) coupling. Upon membrane depolarization, this sensor rapidly triggers Ca(2+) release from internal stores and conducts a slowly activating Ca(2+) current. However, this Ca(2+) current is n...

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Bibliographic Details
Main Authors: Tuluc, Petronel, Molenda, Natalia, Schlick, Bettina, Obermair, Gerald J., Flucher, Bernhard E., Jurkat-Rott, Karin
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2009
Subjects:
Channels, Receptors, and Electrical Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710043/
https://ncbi.nlm.nih.gov/pubmed/19134469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.09.027
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