Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis

Rationale: Loss of iron-sulfur cluster function predisposes cancer cells to ferroptosis by upregulating iron-starvation response, but the role of glutaredoxin 5 (GLRX5) silencing in ferroptosis remains unknown. We examined the role of GLRX5 functional loss in promoting ferroptosis in cisplatin-resis...

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Vydáno v:Theranostics
Hlavní autoři: Lee, Jaewang, You, Ji Hyeon, Shin, Daiha, Roh, Jong-Lyel
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7359084/
https://ncbi.nlm.nih.gov/pubmed/32685019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.46903
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