Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways

Osteoclasts with elevated bone resorption are commonly present in postmenopausal osteoporosis, and other osteolytic pathologies. Therefore, suppressing osteoclast generation and function has been the main focus of osteoporosis treatment. Betulinic acid (BA) represents a triterpenoid mainly purified...

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Vydáno v:Front Pharmacol
Hlavní autoři: Wei, Jiyong, Li, Yicheng, Liu, Qian, Lan, Yanni, Wei, Chengming, Tian, Kun, Wu, Liwei, Lin, Chunbo, Xu, Jiake, Zhao, Jinmin, Yang, Yuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358641/
https://ncbi.nlm.nih.gov/pubmed/32733253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01025
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