Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways

Osteoclasts with elevated bone resorption are commonly present in postmenopausal osteoporosis, and other osteolytic pathologies. Therefore, suppressing osteoclast generation and function has been the main focus of osteoporosis treatment. Betulinic acid (BA) represents a triterpenoid mainly purified...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Wei, Jiyong, Li, Yicheng, Liu, Qian, Lan, Yanni, Wei, Chengming, Tian, Kun, Wu, Liwei, Lin, Chunbo, Xu, Jiake, Zhao, Jinmin, Yang, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358641/
https://ncbi.nlm.nih.gov/pubmed/32733253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01025
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