EGFR activation attenuates the mechanical threshold for integrin tension and focal adhesion formation

Mechanical forces, growth factors and the extracellular matrix all play crucial roles in cell adhesion. To understand how epidermal growth factor receptor (EGFR) impacts the mechanics of adhesion, we employed tension gauge tether (TGT) probes displaying the integrin ligand cRGDfK and quantified inte...

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Vydáno v:J Cell Sci
Hlavní autoři: Rao, Tejeshwar C., Ma, Victor Pui-Yan, Blanchard, Aaron, Urner, Tara M., Grandhi, Shreya, Salaita, Khalid, Mattheyses, Alexa L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358133/
https://ncbi.nlm.nih.gov/pubmed/32546532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.238840
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